Open AccessLINC 00152: A pivotal oncogenic long non‐coding RNA in human cancers
Author(s) -
Yu Yang,
Yang Jian,
Li Quanpeng,
Xu Boming,
Lian Yifan,
Miao Lin
Publication year - 2017
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12349
Subject(s) - oncogene , long non coding rna , cancer research , cancer , suppressor , biomarker , biology , rna , cell cycle , gene , genetics
In recent years, increasing evidence has shown the potential role of long non‐coding RNAs (lncRNAs) in multiple cancers. Deregulation of lnc RNA s was detected being closely associated with many kinds of tumours where they can act as a tumour suppressor or accelerator. LINC 00152 was identified as an oncogene involved in many kinds of cancers, such as gastric cancer, hepatocellular carcinoma, colon cancer, gallbladder cancer and renal cell carcinoma. Moreover, inhibition of LINC 00152 can suppress proliferation, migration and invasion of the cancer cells. Increasing evidence has showed that LINC 00152 may act as a diagnostic and prognostic biomarker for the above‐mentioned cancers. In our review, we summarize the recent research progress of the expression and role of LINC 00152 in various kinds of cancers.