Open AccessRoles of FGFR in oral carcinogenesis
Author(s) -
Xie Xiaoyan,
Wang Zhiyong,
Chen Fangman,
Yuan Yao,
Wang Jiayi,
Liu Rui,
Chen Qianming
Publication year - 2016
Publication title -
cell proliferation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.647
H-Index - 74
eISSN - 1365-2184
pISSN - 0960-7722
DOI - 10.1111/cpr.12260
Subject(s) - fibroblast growth factor receptor , fibroblast growth factor , gene isoform , carcinogenesis , biology , metastasis , cancer , cancer research , signal transduction , receptor , microbiology and biotechnology , genetics , gene
Abstract Fibroblast growth factor receptors ( FGFR s) play essential roles in organ development during the embryonic period, and regulate tissue repair in adults. Accumulating evidence suggests that alterations in FGFR signalling are involved in diverse types of cancer. In this review, we focus on aberrant regulation of FGFR s in pathogenesis of oral squamous cell carcinoma ( OSCC ), including altered expression and subcellular location, aberrant isoform splicing and mutations. We also provide an overview of oncogenic roles of each FGFR and its downstream signalling pathways in regulating OSCC cell proliferation and metastasis. Finally, we discuss potential application of FGFR s as anti‐cancer targets in the preclinical environment and in clinical practice.