Premium
Deep learning‐based quantification of PET/CT prostate gland uptake: association with overall survival
Author(s) -
Polymeri Eirini,
Sadik May,
Kaboteh Reza,
Borrelli Pablo,
Enqvist Olof,
Ulén Johannes,
Ohlsson Mattias,
Trägårdh Elin,
Poulsen Mads H.,
Simonsen Jane A.,
HoilundCarlsen Poul Flemming,
Johnsson Åse A.,
Edenbrandt Lars
Publication year - 2020
Publication title -
clinical physiology and functional imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.608
H-Index - 67
eISSN - 1475-097X
pISSN - 1475-0961
DOI - 10.1111/cpf.12611
Subject(s) - medicine , prostate cancer , voxel , prostate , positron emission tomography , nuclear medicine , standardized uptake value , pet ct , radiology , segmentation , cancer , artificial intelligence , computer science
Summary Aim To validate a deep‐learning (DL) algorithm for automated quantification of prostate cancer on positron emission tomography/computed tomography (PET/CT) and explore the potential of PET/CT measurements as prognostic biomarkers. Material and methods Training of the DL‐algorithm regarding prostate volume was performed on manually segmented CT images in 100 patients. Validation of the DL‐algorithm was carried out in 45 patients with biopsy‐proven hormone‐naïve prostate cancer. The automated measurements of prostate volume were compared with manual measurements made independently by two observers. PET/CT measurements of tumour burden based on volume and SUV of abnormal voxels were calculated automatically. Voxels in the co‐registered 18 F‐choline PET images above a standardized uptake value (SUV) of 2·65, and corresponding to the prostate as defined by the automated segmentation in the CT images, were defined as abnormal. Validation of abnormal voxels was performed by manual segmentation of radiotracer uptake. Agreement between algorithm and observers regarding prostate volume was analysed by Sørensen‐Dice index (SDI). Associations between automatically based PET/CT biomarkers and age, prostate‐specific antigen (PSA), Gleason score as well as overall survival were evaluated by a univariate Cox regression model. Results The SDI between the automated and the manual volume segmentations was 0·78 and 0·79, respectively. Automated PET/CT measures reflecting total lesion uptake and the relation between volume of abnormal voxels and total prostate volume were significantly associated with overall survival ( P = 0·02), whereas age, PSA, and Gleason score were not. Conclusion Automated PET/CT biomarkers showed good agreement to manual measurements and were significantly associated with overall survival.