English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Summary   Introduction  Left ventricular ( LV ) hypertrophy ( LVH ) and reduced  LV  function correlate with poor prognosis in patients with chronic kidney disease ( CKD ). Our aim is to investigate whether mild‐to‐moderate  CKD  is associated with cardiac abnormalities.    Methods  Echocardiography, including tissue Doppler imaging, was performed in 103 patients with  CKD  at stages 2–3 and 4–5, and in 53 healthy controls. The systolic ( s ′) and diastolic myocardial velocity ( e ′), and the transmitral diastolic flow velocity ( E ) were measured, and  E / e ′ was calculated.    Results  Patients with chronic kidney disease had higher mean  E / e ′ than controls (mean  E / e ′: controls 5·00 ± 1·23 versus  CKD  4–5 6·36 ± 1·71,  P <0·001 and versus  CKD  2–3 5·69 ± 1·47,  P  =   0·05), indicating altered diastolic function in the patients. The  CKD  groups showed lower longitudinal systolic function than controls, as assessed by atrio‐ventricular plane displacement and  s ′ (mean  s ′: controls 11·5 ± 1·9 cm s −1  versus  CKD  4–5 10·4 ± 2·1 cm s −1 ,  P  =   0·03 and versus  CKD  2–3 10·4 ± 2·1 cm s −1 ,  P  =   0·02). The prevalence of  LVH  was higher in patients with  CKD  than in controls (controls 13% versus  CKD  4–5 37%,  P  =   0·006 and versus  CKD  2–3 30%,  P  =   0·03).    Conclusion  Alterations in systolic and diastolic myocardial function can be seen in mild‐to‐moderate  CKD  compared with controls, indicating that cardiac involvement starts early in  CKD , which may be a precursor of premature cardiac morbidity.

Cardiac remodelling and functional alterations in mild‐to‐moderate renal dysfunction: comparison with healthy subjects