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Treating nasal symptoms associated with rhinitis using the intranasal herbal ointment Biyeom‐go: A prospective observational study
Author(s) -
Son Mi Ju,
Jung Jeeyoun,
Kim YoungEun,
Yeum ChangSub,
Lee So Min,
Jung So Young,
Kwon Ojin,
Kim Sungha,
Kang JeongIn,
Kim HyeLin,
Lee JungEun,
Lee DongHyo
Publication year - 2019
Publication title -
clinical otolaryngology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.914
H-Index - 68
eISSN - 1749-4486
pISSN - 1749-4478
DOI - 10.1111/coa.13425
Subject(s) - medicine , nasal administration , observational study , prospective cohort study , quality of life (healthcare) , gastroenterology , nasal lavage , nose , surgery , immunology , nursing
Objectives The aim of the current study was to investigate the effectiveness and clinical feasibility of Biyeom‐go for the treatment of nasal symptoms associated with rhinitis. Design Prospective observational study. Setting This study was conducted at the Woosuk Korean Medicine Medical Center in South Korea. Participants Fifty‐eight patients with rhinitis participated in this study. All patients received Biyeom‐go treatment >3 times daily for a total of 4 weeks. Main outcome measures The primary outcome was the total nasal symptom score. Mini‐rhinoconjunctivitis quality of life questionnaire, nasal endoscopy index, total serum immunoglobulin E levels and immunologic factors in nasal lavage fluid were also measured. Results Biyeom‐go administration was associated with significant improvements in total nasal symptoms scores ( P < .0001) and mini‐rhinoconjunctivitis quality of life questionnaire scores ( P < .0001) in a time‐dependent manner. The nasal endoscopy index also significantly improved at weeks 2 ( P = .0049), 3 ( P < .0001) and 4 ( P = .0001) after Biyeom‐go treatment. Significantly, increased interleukin‐2 levels ( P = .005) and decreased interleukin‐8, chemokine (C‐C motif) ligand (CCL) 5, chemokine (C‐X‐C motif) ligand (CXCL) 9, CCL2 and CXCL10 levels were observed in the nasal lavage fluid. Conclusions The present findings suggest that Biyeom‐go may be beneficial for the management of rhinitis symptoms and rhinitis‐associated quality of life. Further well‐designed randomised controlled trials are needed to evaluate the effectiveness of Biyeom‐go for rhinitis.