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Dear Editor,  Tympanic membrane perforation is frequently encountered in outpatient otorhinolaryngology practice. We have introduced a treatment procedure to promote regeneration of the tympanic membrane and closure of perforations using an atelocollagen sponge/silicone membrane combined with human basic fibroblast growth factor that promotes wound healing.1,2 This report describes epithelial pearl formation following our outpatient-based tympanic membrane regeneration therapy.

clinical otolaryngology

Epithelial pearl formation following tympanic membrane regeneration therapy using an atelocollagen/silicone membrane and basic fibroblast growth factor: Our experience from a retrospective study of one hundred sixteen patients