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Summary   Introduction  Vulnerability to psychiatric manifestations is achieved by the influence of genetic and environment including stress and cannabis consumption. Here, we used a psychosocial stress model based on resident‐intruder confrontations to study the brain corticostriatal‐function, since deregulation of corticostriatal circuitries has been reported in many psychiatric disorders.  CB  1  receptors are widely expressed in the central nervous system and particularly, in both cortex and striatum brain structures.    Aims and methods  The investigation presented here is addressed to assess the impact of repeated stress following acute cannabinoid exposure on behavior and corticostriatal brain physiology by assessing mice behavior, the concentration of endocannabinoid and endocannabinoid‐like molecules and changes in the transcriptome.    Results  Stressed animals urinated frequently; showed exacerbated scratching activity, lower striatal  N ‐arachidonylethanolamine ( AEA ) levels and higher cortical expression of cholinergic receptor nicotinic alpha 6. The cannabinoid agonist  WIN 55212.2 diminished locomotor activity while the inverse agonist increased the distance travelled in the center of the open field. Upon  CB  1  activation,  N ‐oleoylethanolamide and  N ‐palmitoylethanolamide, two  AEA  congeners that do not interact directly with cannabinoid receptors, were enhanced in the striatum. The co‐administration with both cannabinoids induced an up‐regulation of striatal  FK 506 binding protein 5. The inverse agonist in controls reversed the effects of  WIN 55212.2 on motor activity. When Rimonabant was injected under stress, the cortical levels of 2‐arachidonoylglycerol were maximum. The agonist and the antagonist influenced the cortical expression of cholinergic receptor nicotinic alpha 6 and serotonin transporter neurotransmitter type 4 in opposite directions, while their co‐administration tended to produce a null effect under stress.    Conclusions  The endocannabinoid system had a direct effect on serotoninergic neurotransmission and glucocorticoid signaling. Cholinergic receptor nicotinic alpha‐6 was shown to be deregulated in response to stress and following synthetic cannabinoid drugs thus could confer vulnerability to cannabis addiction and psychosis. Targeting the receptors of endocannabinoids and endocannabinoid‐like mediators might be a valuable option for treating stress‐related neuropsychiatric symptoms.

cns neuroscience and therapeutics

Effects of repeated long‐term psychosocial stress and acute cannabinoid exposure on mouse corticostriatal circuitries: Implications for neuropsychiatric disorders