Open AccessThe caudal part of the posterior insula of rats participates in the maintenance but not the acquisition of morphine conditioned place preference
Author(s) -
Sun YongMei,
Chen RongXiang,
Li ZhiFei,
Spijker Sabine,
Zhai RongWei,
Yang ShangChuan
Publication year - 2018
Publication title -
cns neuroscience and therapeutics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.403
H-Index - 69
eISSN - 1755-5949
pISSN - 1755-5930
DOI - 10.1111/cns.12799
Subject(s) - conditioned place preference , morphine , insula , lesion , neuroscience , insular cortex , psychology , somatosensory system , addiction , medicine , pharmacology , psychiatry
Summary The heterogeneous insular cortex plays an interoceptive role in drug addiction by signaling the availability of drugs of abuse. Here, we tested whether the caudal part of the multisensory posterior insula ( PI ) stores somatosensory‐associated rewarding memories. Using Sprague Dawley rats as subjects, we first established a morphine‐induced conditioned place preference ( CPP ) paradigm, mainly based on somatic cues. Secondly, an electrolytic lesion of the caudal portion of the PI was carried out before and after the establishment of CPP , respectively. Our data demonstrated that the caudal PI lesions disrupted the maintenance, but not the acquisition of morphine‐induced CPP . Lesion or subtle disruption of the PI had no major impact on locomotor activity. These findings indicate that the caudal portion of the PI might be involved in either the storage or the retrieval of morphine CPP memory.