Open AccessPost‐transcriptional gene regulation in the biology and virulence of Candida albicans
Author(s) -
VermaGaur Jiyoti,
Traven Ana
Publication year - 2016
Publication title -
cellular microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.542
H-Index - 138
eISSN - 1462-5822
pISSN - 1462-5814
DOI - 10.1111/cmi.12593
Subject(s) - biology , virulence , candida albicans , post transcriptional regulation , transcriptional regulation , gene , corpus albicans , gene expression , regulation of gene expression , messenger rna , transcription (linguistics) , microbiology and biotechnology , translation (biology) , antifungal drug , genetics , linguistics , philosophy
Summary In the human fungal pathogen Candida albicans , remodelling of gene expression drives host adaptation and virulence. Recent studies revealed that in addition to transcription, post‐transcriptional mRNA control plays important roles in virulence‐related pathways. Hyphal morphogenesis, biofilm formation, stress responses, antifungal drug susceptibility and virulence in animal models require post‐transcriptional regulators. This includes RNA binding proteins that control mRNA localization, decay and translation, as well as the cytoplasmic mRNA decay pathway. Comprehensive understanding of how modulation of gene expression networks drives C . albicans virulence will necessitate integration of our knowledge on transcriptional and post‐transcriptional mRNA control.