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High‐Resolution Three‐Dimensional Computed Tomography Analysis of the Clinical Efficacy of Cultured Autogenous Periosteal Cells in Sinus Lift Bone Grafting
Author(s) -
Ogawa Shin,
Hoshina Hideyuki,
Nakata Koh,
Yamada Kazuho,
Uematsu Kohya,
Kawase Tomoyuki,
Takagi Ritsuo,
Nagata Masaki
Publication year - 2016
Publication title -
clinical implant dentistry and related research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.338
H-Index - 85
eISSN - 1708-8208
pISSN - 1523-0899
DOI - 10.1111/cid.12356
Subject(s) - medicine , cancellous bone , cortical bone , periosteum , bone grafting , dentistry , anatomy , nuclear medicine
Background and Purpose Sinus lift ( SL ) using cultured autogenous periosteal cells ( CAPCs ) combined with autogenous bone and platelet‐rich plasma ( PRP ) was performed to evaluate the effect of cell administration on bone regeneration, by using high‐resolution three‐dimensional computed tomography ( CT ). Materials and Methods SL with autogenous bone and PRP plus CAPC [ CAPC (+) SL ] was performed in 23 patients. A piece of periosteum taken from the mandible was cultured in M 199 medium with 10% fetal bovine serum ( FBS ) for 6 weeks. As control, 16 patients received SL with autogenous bone and PRP [ CAPC (−) SL ]. Three‐dimensional CT imaging was performed before and 4 months and 1 year after SL , and stratification was performed based on CT numbers ( HUs ) corresponding to soft tissue and cancellous or cortical bone. Results The augmented bone in CAPC (+) SL revealed an increase in HUs corresponding to cancellous bone as well as a decrease in HUs corresponding to grafted cortical bone. In addition, HUs corresponding to cancellous bone in the graft bed were increased in CAPC (+) SL but were decreased in CAPC (−) SL . Insertion torque during implant placement was significantly higher in CAPC (+) SL . Conclusion By promoting bone anabolic activity both in augmented bone and graft bed, CAPCs are expected to aid primary fixation and osseointegration of implants in clinical applications.