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In this study, IgG‐autoantibodies associated with autoimmune hepatitis and primary biliary cholangitis (PBC) were found in a considerable proportion of well‐characterized patients diagnosed with primary Sjögren’s syndrome and systemic lupus erythematosus (SLE) but without known liver involvement or autoimmune liver disease (AILD). PBC‐associated autoantibodies have previously not been reported in a substantial percentage of cases with SLE. However, the association between autoantibody findings and AILD was poor as no significant difference in liver enzymes was observed between AILD‐associated autoantibody negative and positive patients.

clinical & experimental immunology

Autoantibodies associated with primary biliary cholangitis are common among patients with systemic lupus erythematosus even in the absence of elevated liver enzymes