Open AccessmiR‐3184‐3p enriched in cerebrospinal fluid exosomes contributes to progression of glioma and promotes M2‐like macrophage polarization
Author(s) -
Xu Hao,
Li Ming,
Pan Ziwen,
Zhang Zongpu,
Gao Zijie,
Zhao Rongrong,
Li Boyan,
Qi Yanhua,
Qiu Wei,
Guo Qindong,
Zhang Shouji,
Fan Yang,
Zhao Shulin,
Wang Shaobo,
Guo Xing,
Deng Lin,
Xue Hao,
Li Gang
Publication year - 2022
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.15372
Subject(s) - microvesicles , glioma , exosome , cancer research , microrna , tumor progression , apoptosis , macrophage polarization , biology , macrophage , immunology , medicine , in vitro , cancer , gene , biochemistry
Abstract Liquid biopsy is a novel strategy for tumour diagnosis. The contents of cerebrospinal fluid (CSF) exosomes could reflect glioma status, hence sampling exosomes from CSF is a means of liquid biopsy for glioma. However, few studies have focused on the function of microRNAs in CSF exosomes. In this study, we found that miR‐3184‐3p was enriched in CSF exosomes in glioma patients and was downregulated after tumour resection. We found that miR‐3184 facilitates glioma progression in two ways. On the one hand, miR‐3184 directly promotes proliferation, migration, and invasion while inhibiting apoptosis in glioma. On the other hand, miR‐3184 in glioma‐derived exosomes polarizes macrophages to an M2‐like phenotype, which further aggravates tumour progression. Overall, the current findings uncovered a new mechanism and highlighted the significant role of miR‐3184 in glioma progression. Furthermore, exosomal miR‐3184 could be a considerable factor with potential applications in glioma diagnosis and treatment in the future.