Open AccessCirculating naïve and effector memory T cells correlate with prognosis in head and neck squamous cell carcinoma
Author(s) -
Takahashi Hideyuki,
Sakakura Koichi,
Ida Shota,
KawabataIwakawa Reika,
Matsuyama Toshiyuki,
Tada Hiroe,
Mito Ikko,
Chikamatsu Kazuaki
Publication year - 2022
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.15195
Subject(s) - cd38 , head and neck squamous cell carcinoma , cytotoxic t cell , cd8 , tumor microenvironment , t cell , cancer research , biology , memory t cell , cell , immunology , effector , immune system , medicine , in vitro , cancer , stem cell , head and neck cancer , microbiology and biotechnology , biochemistry , genetics , cd34
T‐cell memory is an important mechanism for long‐term protection against diverse pathogens. Generation and persistence of memory T cells are vital components of anti‐tumor immunity, given their ability to persist for prolonged durations, as well as activate and migrate rapidly. In the present study, we investigated the clinical and prognostic significance of T‐cell subsets in the peripheral circulation of patients with head and neck squamous cell carcinoma (HNSCC). Moreover, we calculated the enrichment scores of T‐cell subsets in primary tumor tissues and compared their clinical characteristics using a public database. Multivariate survival analyses of circulating T‐cell parameters revealed that clinical parameters, except M factor, were not independent prognostic factors, whereas proportions of CD8 + T cells, naïve T cells (T N s), effector memory T cells (T EM s), and CD38 + CD8 + T cells were independent prognostic factors, suggesting the importance of these peripheral T‐cell parameters as independent prognostic biomarkers. Consistent with these results, the T‐cell enrichment analysis indicated that enrichment of CD8 + T N s in the tumor microenvironment was an independent prognostic factor. Moreover, an ex vivo experiment demonstrated significantly less cytotoxic activity in CD38 + T cells than in CD38 − T cells. These findings suggest that T‐cell memory‐related parameters in both systemic immunity and the tumor microenvironment could be used as prognostic biomarkers regardless of clinical characteristics. Further characterization of circulating T cells would lead to the development of novel biomarkers for patients with HNSCC.