Open AccessThe prognostic value of TCF1+CD8+T in primary small cell carcinoma of the esophagus
Author(s) -
Ma Lin,
Sun Lijun,
Zhao Kaikai,
Dong Zhengxin,
Huang Zhaoqin,
Meng Xiangjiao
Publication year - 2021
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.15167
Subject(s) - cd8 , cytotoxic t cell , cancer research , carcinoma , immunohistochemistry , esophagus , biology , medicine , immune system , immunology , in vitro , biochemistry
TCF1+CD8+T cells are reported to exhibit stem‐like properties with the ability to self‐renew and differentiate into terminal effector T cells (TCF1‐CD8+T cells) to enhance antitumor response. Previous studies indicated that TCF1+CD8+ tumor‐infiltrating lymphocytes (TILs) are related to response to immunotherapy. However, their role in predicting prognosis for patients with primary small cell carcinoma of the esophagus (PSCCE) remains unclear. In this study, the expression of TCF1+CD8+T was analyzed by multiplex fluorescence immunohistochemistry in tumor tissues of 79 patients with PSCCE. High infiltration of TCF1+CD8+T cells had longer overall survival (OS) than low infiltration ( P = .009, hazard ratio [HR] = 0.506). High TCF1+CD8/CD8 ratio (>21%) showed superior OS compared with low ratio (≤21%) ( P < .001, HR = 0.394). In the validation set (n = 20), the prognostic value of TCF1+CD8+T cells on OS was also verified. TCF1+CD8+T cells are strong prognostic predictors.