English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Melanoma is a fatal skin malignant tumor with a poor prognosis. We found that long noncoding RNA  BASP1  ‐AS1  is essential for the development and prognosis of melanoma. The methylation, RNA sequencing, copy number variation, mutation data, and sample follow‐up information of melanoma from The Cancer Genome Atlas (TCGA) were analyzed using weighted gene co‐expression network analysis and 366 samples common to the three omics were selected for multigroup clustering analysis. A four‐gene prognostic model ( BASP1‐AS1 ,  LOC100506098 ,  ARHGAP27P1 , and  LINC01532 ) was constructed in the TCGA cohort and validated using the  GSE65904  series. The expression of  BASP1‐AS1  was upregulated in melanoma tissues and various melanoma cell lines. Functionally, the ectopic expression of  BASP1‐AS1  promoted cell proliferation, migration, and invasion in both A375 and SK‐MEL‐2 cells. Mechanically,  BASP1‐AS1  interacted with YBX1 and recruited it to the promoter of NOTCH3, initiating its transcription process. The activation of the Notch signaling then resulted in the transcription of multiple oncogenes, including c‐MYC, PCNA, and CDK4, which contributed to melanoma progression. Thus,  BASP1‐AS1  could act as a potential biomarker for cutaneous malignant melanoma.

LncRNA BASP1‐AS1 interacts with YBX1 to regulate Notch transcription and drives the malignancy of melanoma