Open AccessSignal‐transducing innate receptors in tumor immunity
Author(s) -
Hangai Sho,
Kimura Yoshitaka,
Taniguchi Tadatsugu,
Yanai Hideyuki
Publication year - 2021
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.14848
Subject(s) - pattern recognition receptor , innate immune system , receptor , immunity , acquired immune system , biology , immune system , immunology , pathogen associated molecular pattern , intrinsic immunity , signal transduction , neuroscience , microbiology and biotechnology , genetics
The signal‐transducing innate receptors represent classes of pattern recognition receptors (PRRs) that play crucial roles in the first line of the host defense against infections by the recognition of pathogen‐derived molecules. Because of their poorly discriminative nature compared with antigen receptors of the adaptive immune system, they also recognize endogenous molecules and evoke immune responses without infection, resulting in the regulation of tumor immunity. Therefore, PRRs may be promising targets for effective cancer immunotherapy, either by activating or inhibiting them. Here, we summarize our current knowledge of signal‐transducing PRRs in the regulation of tumor immunity.