Open AccessFMS‐like tyrosine kinase 3 ( FLT3 ) amplification in patients with metastatic colorectal cancer
Author(s) -
Hasegawa Hiroko,
Taniguchi Hiroya,
Nakamura Yoshiaki,
Kato Takeshi,
Fujii Satoshi,
Ebi Hiromichi,
Shiozawa Manabu,
Yuki Satoshi,
Masuishi Toshiki,
Kato Ken,
Izawa Naoki,
Moriwaki Toshikazu,
Oki Eiji,
Kagawa Yoshinori,
Denda Tadamichi,
Nishina Tomohiro,
Tsuji Akihito,
Hara Hiroki,
Esaki Taito,
Nishida Tomohiro,
Kawakami Hisato,
Sakamoto Yasutoshi,
Miki Izumi,
Okamoto Wataru,
Yamazaki Kentaro,
Yoshino Takayuki
Publication year - 2021
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.14693
Subject(s) - regorafenib , colorectal cancer , medicine , oncology , gene duplication , cancer research , tyrosine kinase , receptor tyrosine kinase , cancer , gene , biology , receptor , genetics
Abstract FMS‐like tyrosine kinase 3 (FLT3) plays a key role in hematopoiesis. However, the oncogenic role of FLT3 amplification in patients with metastatic colorectal cancer (mCRC) remains unclear. Here, we aimed to evaluate the characteristics, prognosis, and treatment efficacy of an FLT3 inhibitor (regorafenib) in patients with mCRC with FLT3 amplifications. Tumor tissue samples from 2329 patients were sequenced using NGS in the Nationwide Cancer Genome Screening Project in Japan. The effects of clinicopathological features, co‐altered genes, prognosis, and efficacy of regorafenib were investigated. Between April 2015 and June 2018, 85 patients with mCRC with FLT3 amplification were observed. There were no differences in baseline characteristics between patients with or without FLT3 amplification. The frequency of RAS or other gene co‐alterations was inversely correlated with the copy number status. Median survival time in patients with FLT3 amplification was significantly shorter compared with those with non‐ FLT3 amplification. Further investigations of FLT3 amplification as a potential treatment target in mCRC are warranted.