Open AccessDiagnostic performance of peripheral leukocyte telomere G‐tail length for detecting breast cancer
Author(s) -
Koi Yumiko,
Tsutani Yasuhiro,
Nishiyama Yukie,
Kanda Miyuki,
Shiroma Yoshitomo,
Yamamoto Yuki,
Sasada Shinsuke,
Akita Tomoyuki,
Masumoto Norio,
Kadoya Takayuki,
Takahashi Ryouu,
Tanaka Junko,
Okada Morihito,
Tahara Hidetoshi
Publication year - 2020
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.14378
Subject(s) - telomere , breast cancer , peripheral , biomarker , cancer , peripheral blood , biology , medicine , oncology , genetics , dna
The telomere G‐tail (G‐tail) plays an essential role in maintaining chromosome stability. In this study, we assessed the leukocyte G‐tail length of breast cancer (BC) patients and cancer‐free individuals and evaluated the association between the G‐tail length and the presence of BC. A significant shortening of the median G‐tail length was observed in BC patients compared with cancer‐free individuals and was found in the early phase of BC. Our study indicated that the leukocyte G‐tail length might be a potential biomarker for BC detection.