Open AccessImmunological features of a lung cancer patient achieving an objective response with anti‐programmed death‐1 blockade therapy
Author(s) -
Kamata Toshiko,
Yoshida Shigetoshi,
Takami Mariko,
Ihara Fumie,
Yoshizawa Hiroko,
Toyoda Takahide,
Takeshita Yuichiro,
Nobuyama Seiichi,
Kanetsuna Yukiko,
Sato Tetsuo,
Yoshino Ichiro,
Motohashi Shinichiro
Publication year - 2020
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.14222
Subject(s) - medicine , germinal center , immune system , lung cancer , immunotherapy , blockade , immune checkpoint , infiltration (hvac) , tumor microenvironment , oncology , cancer research , immunology , antibody , b cell , receptor , thermodynamics , physics
The role of immune checkpoint inhibitors in metastatic lung cancer has been established in recent years and the pretherapeutic profiles of the tumor microenvironment in responders have been increasingly reported. The role of salvage surgery and the immune profiles of the posttherapeutic specimens in patients achieving an objective response have rarely been studied. We report a case of metastatic lung cancer treated by anti‐programmed death‐1 Ab followed by surgical resection. The immune status of the tumor was assessed, showing germinal center formation, memory B cell infiltration, and a high frequency of interferon gamma ‐secreting T cells.