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NOP 2/Sun domain family, member 2 ( NSUN 2) is a nuclear  RNA  methyl‐transferase catalyzing 5‐methylcytosine formation. Evidence shows that  NSUN 2 is correlated with cell unlimited proliferation. However, its functional role in gallbladder carcinoma ( GBC ), which is the most common biliary tract malignancy and has a poor prognosis, remains to be determined. Here we found that  NSUN 2 was highly expressed in  GBC  tissues as well as cell lines.  NSUN 2 silencing repressed  GBC  cell proliferation and tumorigenesis both in vitro and in vivo. Conversely, upregulation of  NSUN 2 enhanced  GBC  cell growth and colony formation. We further discovered that  RPL 6 was a closely interacting partner with  NSUN 2. Silencing  RPL 6 resulted in insufficient  NSUN 2 translational level and accumulative  NSUN 2 transcriptional level. Exogenous expression of  NSUN 2 partially rescued the effect of  RPL 6 in gallbladder cancer progression. Taken together, our data provided novel mechanic insights into the function of  NSUN 2 in  GBC , thus pointing to  NSUN 2 as a potential and effective therapeutic approach to  GBC  treatment.

NOP 2/Sun RNA methyltransferase 2 promotes tumor progression via its interacting partner RPL 6 in gallbladder carcinoma