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Multi‐walled carbon nanotube‐7 ( MWCNT ‐7) fibers are biopersistent and have a structure similar to asbestos.  MWCNT ‐7 has been shown to induce malignant mesothelioma when administered by intrascrotal or intraperitoneal injection in rats and mice, and an inhalation study demonstrated that rats exposed to respirable  MWCNT ‐7 developed lung tumors.  MWCNT ‐N, which is similar to  MWCNT ‐7, was shown to induce both lung tumors and malignant mesothelioma in rats when administered by trans‐tracheal intrapulmonary spraying ( TIPS ). The present study was performed to investigate the carcinogenicity of  MWCNT ‐7 when administered by the  TIPS  method. Ten‐week‐old male F344/Crj rats were divided into 3 groups and administered 0.5  mL  vehicle, 0.250 μg/ mL MWCNT ‐7 or 0.250 μg/ mL  crocidolite once a week for 12 weeks (total doses of 1.5 mg/rat) and then observed for up to 104 weeks. Rats in the  MWCNT ‐7 group began to die from pathologies associated with the development of malignant mesothelioma 35 weeks after the final  TIPS  administration. Overall, the incidence of malignant mesothelioma in the  MWCNT ‐7 group was significantly higher than in the vehicle or crocidolite groups.

MWCNT ‐7 administered to the lung by intratracheal instillation induces development of pleural mesothelioma in F344 rats