Open AccessPrognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma
Author(s) -
Kuwabara Shota,
Tsuchikawa Takahiro,
Nakamura Toru,
Hatanaka Yutaka,
Hatanaka Kanako C.,
Sasaki Katsunori,
Ono Masato,
Umemoto Kazufumi,
Suzuki Tomohiro,
Sato Osamu,
Hane Yuma,
Nakanishi Yoshitsugu,
Asano Toshimichi,
Ebihara Yuma,
Kurashima Yo,
Noji Takehiro,
Murakami Soichi,
Okamura Keisuke,
Shichinohe Toshiaki,
Hirano Satoshi
Publication year - 2019
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.14023
Subject(s) - chemoradiotherapy , medicine , pancreatic cancer , immunohistochemistry , adenocarcinoma , pancreatic ductal adenocarcinoma , clinical significance , tumor microenvironment , neoadjuvant therapy , cancer , oncology , pathology , gastroenterology , breast cancer
The efficacy of preoperative neoadjuvant chemoradiotherapy ( NAC ) in cases of pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect prognoses following chemoradiotherapy using tertiary lymphoid organs ( TLO ) expressed in the tumor microenvironment. Resected tumor specimens were obtained from 140 pancreatic cancer patients. We retrospectively investigated the clinical relevance of TLO by categorizing patients into those who underwent upfront surgery (surgery first [ SF ]) and those who received NAC. The immunological elements within TLO were analyzed by immunohistochemistry ( IHC ). In the IHC analysis, the proportions of CD 8+ T lymphocytes, PNA d+ high endothelial venules, CD 163+ macrophages and Ki‐67+ cells within the TLO were higher in the NAC group than in the SF group. In contrast, the proportion of programmed cell death‐1+ immunosuppressive lymphocytes within TLO was lower in the NAC group than in the SF group. The NAC group demonstrated favorable prognoses compared with the SF group. In the multivariate analysis, the TLO /tumor ratio was determined as an independent predictive prognostic factor. In conclusion, the administration of preoperative chemoradiotherapy may influence the immunological elements in the tumor microenvironment and result in favorable prognoses in pancreatic ductal adenocarcinoma patients.