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Increasing numbers of studies have confirmed that long noncoding  RNA  (lnc RNA ) play a critical role in epithelial ovarian cancer ( EOC ) progression. However, the potential function of the lnc RNA  tumor protein translationally controlled 1 ( TPT 1) antisense  RNA  1 ( TPT 1‐ AS 1) in  EOC  is unclear. In this study, we aimed to uncover the biological roles and regulatory mechanisms of  TPT 1‐ AS 1 in  EOC  progression and metastasis. First,  TPT 1‐ AS 1 expression was significantly higher in  EOC  metastatic tissue and cell lines than in their respective control counterparts. In addition, ectopic  TPT 1‐ AS 1 expression was strongly associated with unfavorable  EOC  clinicopathological features, including  FIGO  stage, tumor size and tumor differentiation.  TPT 1‐ AS 1 overexpression remarkably induced cell proliferation, migration and invasion, and significantly attenuated cell adhesion ability in vitro and facilitated nude mouse subcutaneous xenograft growth and intraperitoneal metastasis in vivo, while the downregulation of  TPT 1‐ AS 1 expression produced the opposite effect in vitro. Mechanistically,  TPT 1‐ AS 1 was proven to be primarily distributed in  EOC  cell nuclei and positively modulated  TPT 1 promoter activity and transcription. Moreover, the oncogenic effects of  TPT 1‐ AS 1 could be reversed by  TPT 1 depletion, and the  PI 3K/ AKT  signaling pathway downstream of  TPT 1 was also altered. These results suggested that  TPT 1‐ AS 1 induced  EOC  tumor growth and metastasis through  TPT 1 and downstream  PI 3K/ AKT  signaling and that  TPT 1‐ AS 1 may be a promising therapeutic target for  EOC .

Lnc RNA TPT 1‐ AS 1 promotes tumorigenesis and metastasis in epithelial ovarian cancer by inducing TPT 1 expression