English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Y‐box binding protein‐1 ( YBX 1), a multifunctional oncoprotein containing an evolutionarily conserved cold shock domain, dysregulates a wide range of genes involved in cell proliferation and survival, drug resistance, and chromatin destabilization by cancer. Expression of a multidrug resistance‐associated  ATP  binding cassette transporter gene,   ABCB 1 , as well as growth factor receptor genes,   EGFR   and   HER 2/ErbB2 , was initially discovered to be transcriptionally activated by  YBX 1 in cancer cells. Expression of other drug resistance‐related genes,   MVP / LRP  ,   TOP 2A ,   CD 44 ,   CD 49f ,   BCL 2 ,   MYC  , and androgen receptor (  AR  ), is also transcriptionally activated by  YBX 1, consistently indicating that  YBX 1 is involved in tumor drug resistance. Furthermore, there is strong evidence to support that nuclear localization and/or overexpression of  YBX 1 can predict poor outcomes in patients with more than 20 different tumor types.  YBX 1 is phosphorylated by kinases, including  AKT , p70S6K, and p90 RSK , and translocated into the nucleus to promote the transcription of resistance‐ and malignancy‐related genes. Phosphorylated  YBX 1, therefore, plays a crucial role as a potent transcription factor in cancer. Herein, a novel anticancer therapeutic strategy is presented by targeting activated  YBX 1 to overcome drug resistance and malignant progression.

Oncogenic Y‐box binding protein‐1 as an effective therapeutic target in drug‐resistant cancer