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Tumor cells overexpress amino acid transporters to meet the increased demand for amino acids.  PQ  loop repeat‐containing ( PQLC )2 is a cationic amino acid transporter that might be involved in cancer progression. Here, we show that upregulation of  PQLC 2 is critical to gastric cancer ( GC ) development in vitro and in vivo. Both  PQLC 2  mRNA  and protein were overexpressed in  GC  tissues, especially of the diffuse type. Overexpression of  PQLC 2 promoted cell growth, anchorage independence, and tumor formation in nude mice. This was due to activation of  MEK / ERK 1/2 and  PI 3K/ AKT  signaling. Conversely,  PQLC 2 knockdown caused growth arrest and cell death of cancer cells and suppressed tumor growth in a mouse xenograft model. These results suggest that targeting  PQLC 2 is an effective strategy for  GC  treatment.

Cationic amino acid transporter PQLC 2 is a potential therapeutic target in gastric cancer