English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

The   PHLDA   family (pleckstrin homology‐like domain family) of genes consists of 3 members:   PHLDA 1 ,  2 , and  3 . Both  PHLDA 3 and  PHLDA 2 are phosphatidylinositol ( PIP ) binding proteins and function as repressors of Akt. They have tumor suppressive functions, mainly through Akt inhibition. Several reports suggest that  PHLDA 1 also has a tumor suppressive function; however, the precise molecular functions of  PHLDA 1 remain to be elucidated. Through a comprehensive screen for p53 target genes, we identified   PHLDA 1  as a novel p53 target, and we show that  PHLDA 1 has the ability to repress Akt in a manner similar to that of  PHLDA 3 and  PHLDA 2.  PHLDA 1 has a so‐called split  PH  domain in which the  PH  domain is divided into an N‐terminal (β sheets 1‐3) and a C‐terminal (β sheets 4‐7 and an α‐helix) portions. We show that the  PH  domain of  PHLDA 1 is responsible for its localization to the plasma membrane and binding to phosphatidylinositol. We also show that the function of the  PH  domain is essential for Akt repression. In addition,   PHLDA 1  expression analysis suggests that  PHLDA 1 has a tumor suppressive function in breast and ovarian cancers.

PHLDA 1, another PHLDA family protein that inhibits Akt