Open AccessRole of fibroblast growth factor receptor 4 in cancer
Author(s) -
Tang Shuya,
Hao Yilong,
Yuan Yao,
Liu Rui,
Chen Qianming
Publication year - 2018
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13759
Subject(s) - fibroblast growth factor receptor , fibroblast growth factor , signal transduction , cancer research , cancer , receptor , fibroblast growth factor receptor 3 , biology , fibroblast growth factor receptor 1 , microbiology and biotechnology , genetics
Fibroblast growth factor receptors ( FGFR ) play a significant role in both embryonic development and in adults. Upon binding with ligands, FGFR signaling is activated and triggers various downstream signal cascades that are implicated in diverse biological processes. Aberrant regulations of FGFR signaling are detected in numerous cancers. Although FGFR 4 was discovered later than other FGFR , information on the involvement of FGFR 4 in cancers has significantly increased in recent years. In this review, the recent findings in FGFR 4 structure, signaling transduction, physiological function, aberrant regulations, and effects in cancers as well as its potential applications as an anticancer therapeutic target are summarized.