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Myeloid‐derived suppressor cells ( MDSC ) are a heterogeneous population of immature myeloid cells which consist of 2 subsets: granulocytic  MDSC  (G‐ MDSC ) and monocytic  MDSC  (M‐ MDSC ).  MDSC  expand in tumor‐bearing hosts and contribute to immunotherapeutic resistance by remarkably blocking effector T‐cell activation via different mechanisms. Resveratrol ( RSV ) is a polyphenol and it has been widely used for its various health benefits. However, the underlying mechanism of its anti‐tumor properties remains unclear. In this study, a transplantable mouse model was used to investigate the effects of  RSV  on  MDSC . The results showed that  RSV  ameliorated tumor development by decreasing G‐ MDSC  accumulation, impairing its suppressive ability on  CD 8 + T cells and promoting M‐ MDSC  differentiation into  CD 11c +  and F4/80 +  cells. Our results indicated that  RSV  should be considered as a modular of  MDSC  suppressive function and that  RSV  is a novel booster for tumor immunotherapy.

cancer science

Resveratrol ameliorates Lewis lung carcinoma‐bearing mice development, decreases granulocytic myeloid‐derived suppressor cell accumulation and impairs its suppressive ability