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Osteosarcoma is the most common primary bone malignancy. Recently, studies showed chemokine receptor 4 ( CXCR 4) played a critical role in osteosarcoma. However, the regulation of  CXCR 4 is not fully understood. micro RNA s are short, non‐coding  RNA s that play an important roles in post‐transcriptional regulation of gene expression in a variety of diseases including osteosarcoma. miR‐613 is a newly discovered mi RNA  and has been reported to function as a tumor suppressor in many cancers. In this study, we confirmed that both Stromal Cell‐Derived Factor ( SDF ‐1) and  CXCR 4 could be prognostic markers for osteosarcoma. Meanwhile this study found that  SDF ‐1/ CXCR 4 pathway regulated osteosarcoma cells proliferation, migration and reduced apoptosis. Besides, we demonstrated that miR‐613 was significantly downregulated in osteosarcoma patients. Elevated expression of miR‐613 directly suppressed  CXCR 4 expression and then decreased the proliferation, migration and induced apoptosis of osteosarcoma cells. Moreover, our study found that  CXCR 4 promoted the development of lung metastases and inhibition of  CXCR 4 by miR‐613 reduced lung metastases. These data indicated that  CXCR 4 mediated osteosarcoma cell growth and lung metastases and this effect can be suppressed by miR‐613 through directly downregulating  CXCR 4.

CXCR 4‐mediated osteosarcoma growth and pulmonary metastasis is suppressed by Micro RNA ‐613