English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Near infrared photoimmunotherapy ( NIR ‐ PIT ) is a highly selective tumor treatment that employs an antibody‐photo‐absorber conjugate ( APC ) which is activated by near infrared light. Here, we describe the efficacy of endoscopic  NIR ‐ PIT  using the  APC  trastuzumab‐ IR 700 DX  (tra‐ IR 700) in the setting of human epidermal growth factor 2 positive ( HER 2 + ) gastric carcinoma with peritoneal disseminations. In this in vivo study, fluorescence endoscopy showed high tumor accumulation of tra‐ IR 700 within disseminated peritoneal implants. Mice with disseminated peritoneal gastric cancer were separated into 4 groups: (i) control (no treatment); (ii) tra‐ IR 700 i.v. only; (iii)  NIR  light only; and (iv) endoscopic  NIR ‐ PIT .  NIR  light irradiation was carried out through a fiber optic diffuser under endoscopic guidance. In vivo bioluminescence images showed significantly greater therapeutic effect in the endoscopic  NIR ‐ PIT  group than that in the control groups ( P  < .01 vs other control groups). Histological analysis showed diffuse cancer cell death in  NIR ‐ PIT ‐treated tumors. In conclusion,  NIR ‐ PIT  with  NIR  light delivered via an endoscopic fiber optic diffuser is a promising method for the treatment of peritoneal dissemination of gastric cancer. Moreover, this technique could be readily used in other types of cancers with peritoneal dissemination provided that suitable antibodies could be found.

Endoscopic near infrared photoimmunotherapy using a fiber optic diffuser for peritoneal dissemination of gastric cancer