Open AccessPrognostic value of nutritional risk screening 2002 scale in nasopharyngeal carcinoma: A large‐scale cohort study
Author(s) -
Peng Hao,
Chen BinBin,
Tang LingLong,
Chen Lei,
Li WenFei,
Zhang Yuan,
Mao YanPing,
Sun Ying,
Liu LiZhi,
Tian Li,
Guo Ying,
Ma Jun
Publication year - 2018
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13603
Subject(s) - medicine , nasopharyngeal carcinoma , cohort , gastroenterology , area under the curve , oncology , survival analysis , radiation therapy
Little is known about the value of the nutritional risk screening 2002 ( NRS 2002) scale in nasopharyngeal carcinoma ( NPC ). We conducted a large‐scale study to address this issue. We employed a big‐data intelligence database platform at our center and identified 3232 eligible patients treated between 2009 and 2013. Of the 3232 (12.9% of 24 986) eligible patients, 469 (14.5%), 13 (0.4%), 953 (29.5%), 1762 (54.5%) and 35 (1.1%) had NRS 2002 scores of 1, 2, 3, 4 and 5, respectively. Survival outcomes were comparable between patients with NRS 2002 <3 and ≥3 (original scale). However, patients with NRS 2002 ≤3 vs >3 (regrouping scale) had significantly different 5‐year disease‐free survival ( DFS ; 82.7% vs 75.0%, P < .001), overall survival ( OS ; 88.8% vs 84.1%, P = .001), distant metastasis‐free survival ( DMFS ; 90.2% vs 85.9%, P = .001) and locoregional relapse‐free survival ( LRRFS ; 91.6% vs 87.2%, P = .001). Therefore, we proposed a revised NRS 2002 scale, and found that it provides a better risk stratification than the original or regrouping scales for predicting DFS (area under the curve [ AUC ] = 0.530 vs 0.554 vs 0.577; P < .05), OS ( AUC = 0.534 vs 0.563 vs 0.582; P < .05), DMFS ( AUC = 0.531 vs 0.567 vs 0.590; P < .05) and LRRFS ( AUC = 0.529 vs 0.542 vs 0.564; P < .05 except scale A vs B). Our proposed NRS 2002 scale represents a simple, clinically useful tool for nutritional risk screening in NPC .