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Breast cancer ( BC ) is an aggressive malignant disease in women worldwide with a high tendency to metastasize. However, important biomarkers for  BC  metastasis remain largely undefined. In the present study, we identified that long non‐coding  RNA ‐ CTD ‐2108O9.1 is downregulated in  BC  tissues and cells and acts as a metastatic inhibitor of  BC . Mechanistic investigation determined that lnc RNA ‐ CTD ‐2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor ( LIFR ), which is designated as a metastasis suppressor in  BC . Our study characterizes a significant tumor suppressor active in  BC  metastasis repression through the known metastasis inhibitor  LIFR .

Long non‐coding RNA ‐ CTD ‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor