Open AccessLong non‐coding RNA ‐ CTD ‐2108O9.1 represses breast cancer metastasis by influencing leukemia inhibitory factor receptor
Author(s) -
Wang Mozhi,
Wang Mengshen,
Wang Zhenning,
Yu Xueting,
Song Yongxi,
Wang Chong,
Xu Yujie,
Wei Fengheng,
Zhao Yi,
Xu Yingying
Publication year - 2018
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13592
Subject(s) - leukemia inhibitory factor receptor , metastasis , cancer research , leukemia inhibitory factor , breast cancer , long non coding rna , biology , metastasis suppressor , leukemia , rna , cancer , immunology , medicine , gene , genetics , interleukin 6 , cytokine
Breast cancer ( BC ) is an aggressive malignant disease in women worldwide with a high tendency to metastasize. However, important biomarkers for BC metastasis remain largely undefined. In the present study, we identified that long non‐coding RNA ‐ CTD ‐2108O9.1 is downregulated in BC tissues and cells and acts as a metastatic inhibitor of BC . Mechanistic investigation determined that lnc RNA ‐ CTD ‐2108O9.1 represses metastasis by targeting leukemia inhibitory factor receptor ( LIFR ), which is designated as a metastasis suppressor in BC . Our study characterizes a significant tumor suppressor active in BC metastasis repression through the known metastasis inhibitor LIFR .