English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Gallbladder cancer ( GBC ) is the most common malignant tumor of the biliary tract system. Epithelial–mesenchymal transition ( EMT ) plays a vital role in the process of tumor metastasis. Mesenchymal‐like cells can serve as a source of cancer stem cells, which can confer the  EMT  phenotype. Placental growth factor ( PLGF ) belongs to the vascular endothelial growth factor family and plays a vital role in cancer. However, the underlying molecular mechanisms about the influence of  PLGF  on  EMT  in  GBC  remain unknown. Here we show that  PLGF  expression levels were higher in  GBC  tissues than in normal adjacent tissues and were associated with poor prognosis in  GBC  patients. Exogenous  PLGF  enhanced the migration, invasion, and tumorsphere formation of  GBC  cells. Conversely, knockdown of  PLGF  decreased the aggressive phenotype of  GBC  cells. Mechanistically, exogenous  PLGF  upregulated micro RNA ‐19a (miR‐19a) expression through the activation of c‐ MYC . Moreover, Spearman's correlation analysis showed a positive pairwise correlation among  PLGF , c‐ MYC , and miR‐19a expression in  GBC  tissues. Taken together, these results suggest that  PLGF  promotes  EMT  and tumorsphere formation through inducing miR‐19a expression by upregulating c‐ MYC . Thus,  PLGF  could be a promising molecular therapeutic target for  GBC .

The PLGF /c‐ MYC /miR‐19a axis promotes metastasis and stemness in gallbladder cancer