Open AccessImplementation of “clinical sequencing” in cancer genome medicine in Japan
Author(s) -
Kohno Takashi
Publication year - 2018
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13486
Subject(s) - dna sequencing , medicine , computational biology , multiplex , genome , clinical practice , precision medicine , personalized medicine , gene , oncology , bioinformatics , biology , genetics , pathology , family medicine
In oncology, actionable mutations (alterations) in cancer‐associated genes are critical in terms of the selection of therapeutic approaches. Next‐generation sequencing of tumor sample DNA (ie, clinical sequencing) can guide clinical management by providing diagnostic or prognostic data, and facilitating the identification of potential treatment regimens, such as molecular‐targeted and immune checkpoint blockade therapies. In the USA , a variety of tumor‐profiling multiplex gene panels have been developed and implemented for this purpose. In Japan, several academic institutions have now carried out detailed investigations of the feasibility and value of clinical sequencing, and cancer societies have issued consensus clinical practice guidance for next‐generation sequencing‐based gene panel tests. These efforts will facilitate the implementation of cancer genome medicine in Japan.