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Invasion and metastasis are crucially important factors in the survival of malignant tumors. Epithelial‐mesenchymal transition ( EMT ) is an early step in metastatic progression and the presence of cancer stem cells is closely related to tumor survival, proliferation, metastasis, and recurrence. Herein we report that ectopic overexpression of micro RNA  26b (miR‐26b) in colorectal cancer ( CRC ) cell lines promoted  EMT  and stem cell‐like phenotypes in vitro. Furthermore, miR‐26b directly targeted and suppressed multiple tumor suppressors, including phosphatase and tensin homolog ( PTEN ) and wingless‐type  MMTV  integration site family member 5A ( WNT 5A). Notably, miR‐26b is markedly upregulated in tumor samples from patients with lymphatic metastases. These results indicate that miR‐26b promotes  CRC  metastasis by downregulating  PTEN  and  WNT 5A, and may represent a therapeutic target for metastatic  CRC .

cancer science

Micro RNA  26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless‐type  MMTV  integration site family member 5A