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An aberrantly elevated expression of  DNA  polymerase ι (Pol ι) is significantly associated with poor prognosis of patients with esophageal squamous cell carcinoma ( ESCC ), yet the mechanisms behind this phenomenon remain obscure. Based on the  RNA ‐Seq transcriptome and real‐time  PCR  analysis, we identified  ETS ‐1 as a candidate gene involved in Pol ι‐mediated progression of  ESCC . Wound‐healing and transwell assay indicated that downregulation of  ETS ‐1 attenuates Pol ι‐mediated invasiveness of  ESCC . Signaling pathway analysis showed that Pol ι enhances  ETS ‐1 phosphorylation at threonine‐38 through the Erk signaling pathway in  ESCC  cells. Kaplan–Meier analysis, based on 93 clinical tissue samples, revealed that  ETS ‐1 phosphorylation at threonine‐38 is associated with poor prognosis of  ESCC  patients. The present study thus demonstrates that phosphorylation of  ETS ‐1 is a critical event in the Pol ι‐induced invasion and metastasis of  ESCC .

Phosphorylation of ETS ‐1 is a critical event in DNA polymerase iota‐induced invasion and metastasis of esophageal squamous cell carcinoma