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In cancer cells the small compounds erastin and  RSL 3 promote a novel type of cell death called ferroptosis, which requires iron‐dependent accumulation of lipid reactive oxygen species. Here we assessed the contribution of lipid peroxidation activity of lipoxygenases ( LOX ) to ferroptosis in oncogenic Ras‐expressing cancer cells. Several 12/15‐ LOX  inhibitors prevented cell death induced by erastin and  RSL 3. Furthermore, si RNA ‐mediated silencing of   ALOX 15  significantly decreased both erastin‐induced and  RSL 3‐induced ferroptotic cell death, whereas exogenous overexpression of  ALOX 15 enhanced the effect of these compounds. Immunofluorescence analyses revealed that the  ALOX 15 protein consistently localizes to cell membrane during the course of ferroptosis. Importantly, treatments of cells with  ALOX 15‐activating compounds accelerated cell death at low, but not high doses of erastin and  RSL 3. These observations suggest that tumor ferroptosis is promoted by  LOX ‐catalyzed lipid hydroperoxide generation in cellular membranes.

Lipoxygenase‐mediated generation of lipid peroxides enhances ferroptosis induced by erastin and RSL3