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Solasodine is a main active component isolated from  Solanum incanum  L. that performs a wide range of functions containing anti‐oxidant, anti‐infection, and neurogenesis promotion. In this study, we explored the influence of solasodine on three types of human colorectal cancer ( CRC ) cell lines. The results show that solasodine prohibited  CRC  cell proliferation dose‐ and time‐dependently and impeded  CRC  cell motility by downregulating  MMP s. Solasodine was also found to fuel caspase‐cascade reaction and increase the ratio between Bax and Bcl‐2 so as to induce  CRC  cell apoptosis. When cells were pretreated with  AKT  activator (insulin‐like growth factor‐1) followed by solasodine, the solasodine‐induced apoptosis was partially abrogated by insulin‐like growth factor‐1. Moreover, solasodine hindered tumor development and stimulated similar mechanisms  in vivo . In general, our study provides the first evidence that solasodine has a suppressive effect on  CRC  cells and that this agent may be a novel therapeutic drug for  CRC  treatment.

Solasodine inhibits human colorectal cancer cells through suppression of the AKT /glycogen synthase kinase‐3β/β‐catenin pathway