Open AccessLong non‐coding RNAs and prostate cancer
Author(s) -
Misawa Aya,
Takayama Kenichi,
Inoue Satoshi
Publication year - 2017
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13352
Subject(s) - prostate cancer , overdiagnosis , carcinogenesis , androgen receptor , long non coding rna , cancer , disease , cancer biomarkers , biology , pca3 , prostate , medicine , rna , biomarker , cancer research , bioinformatics , computational biology , gene , genetics
Long non‐coding RNAs (lncRNAs) are RNA transcripts larger than 200 nucleotides that do not code for proteins the aberrant expression of which has been documented in various types of cancer, including prostate cancer. Lack of appropriate sensitive and specific biomarkers for prostate cancer has led to overdiagnosis and overtreatment, making lncRNAs promising novel biomarkers as well as therapeutic targets for the disease. The present review attempts to summarize the current knowledge of lncRNA expression patterns and mechanisms in prostate cancer, which contribute to carcinogenesis. In particular, we focused on lncRNAs regulated by androgen receptor and expressed in castration‐resistant prostate cancer.