Open AccessMicrotubule actin cross‐linking factor 1, a novel potential target in cancer
Author(s) -
Miao Zhiping,
Ali Arshad,
Hu Lifang,
Zhao Fan,
Yin Chong,
Chen Chu,
Yang Tuanmin,
Qian Airong
Publication year - 2017
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13344
Subject(s) - cancer , microtubule , cancer research , biology , metastasis , actin cytoskeleton , cancer cell , signal transduction , cell growth , cell migration , cell cycle , microbiology and biotechnology , cell , cytoskeleton , genetics
Cancer is a polygenic disease characterized by uncontrolled growth of normal body cells, deregulation of the cell cycle as well as resistance to apoptosis. The spectraplakin protein microtubule actin cross‐linking factor 1 ( MACF 1) plays an essential function in various cellular processes, including cell proliferation, migration, signaling transduction and embryo development. MACF 1 is also involved in processes such as metastatic invasion in which cytoskeleton organization is a critical element that contributes to tumor progression in various human cancers. Aberrant expression of MACF 1 initiates the tumor cell proliferation, and migration and metastasis in numerous cancers, such as breast cancer, colon cancer, lung cancer and glioblastoma. In this review, we summarized the current knowledge of MACF 1 and its critical role in different human cancers. This will be helpful for researchers to investigate the novel functional role of MACF 1 in human cancers and as a potential target to enhance the efficacy of therapeutic treatment modalities.