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Gastric cancer is one of the most common malignant tumors. Although improvement in chemotherapy has been achieved, the clinical prognosis of advanced gastric cancer remains poor. Therefore, it is increasingly important to predict the prognosis and determine whether patients should or should not receive neoadjuvant or adjuvant chemotherapy. Leucine‐rich α2‐glycoprotein‐1 ( LRG 1) is overexpressed during inflammation and is associated with various malignancies. In this study, we assessed  LRG 1 expression in cancer specimens and in the sera of patients with cancer to clarify the usefulness of  LRG 1 as a biomarker in gastric cancer. This study enrolled 239 (for immunohistochemical staining;  IHC ) and 184 (for  ELISA ) patients with gastric cancer. Results of  IHC  showed that  LRG 1 expression was significantly associated with histological type, lymphatic and venous invasion, tumor and node factors, and disease stage. Overall survival was significantly worse in the high  LRG 1 expression group than in the low  LRG 1 group ( P  = 0.0003). Cox multivariate analysis of overall survival revealed that  LRG 1 expression was an independent prognostic factor ( P  = 0.0258). Serum  LRG 1 was significantly higher in gastric cancer patients than in healthy volunteers, and increased as the pathological stage progressed. Furthermore, a significant correlation was revealed between serum  LRG 1 level and  LRG 1 expression with  IHC  ( P <  0.0001). Inhibition of  LRG 1 significantly decreased cell proliferation  in vitro  (migratory and invasive capacity of gastric cancer cells). These results suggest that  LRG 1 expression in tumors and serum may be a useful prognostic marker in gastric cancer patients.

Overexpression of leucine‐rich α2‐glycoprotein‐1 is a prognostic marker and enhances tumor migration in gastric cancer