Open AccessImplication of chemo‐resistant memory T cells for immune surveillance in patients with sarcoma receiving chemotherapy
Author(s) -
Shibayama Yuji,
Tsukahara Tomohide,
Emori Makoto,
Murata Kenji,
Mizushima Emi,
Hirohashi Yoshihiko,
Kanaseki Takayuki,
Nakatsugawa Munehide,
Kubo Terufumi,
Yamashita Toshihiko,
Sato Noriyuki,
Torigoe Toshihiko
Publication year - 2017
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13319
Subject(s) - ctl* , chemotherapy , sarcoma , medicine , immune system , antigen , immunology , cytotoxic t cell , cancer research , biology , pathology , cd8 , in vitro , biochemistry
Chemotherapy has improved the prognosis of patients with sarcomas. However, it may suppress anti‐tumor immunity. Recently, we reported a novel CD 8 + memory T cell population with a chemo‐resistance property, “young memory” T ( T YM ) cells. In this study, we investigated the proportion and function of T YM cells in peripheral blood of healthy donors and sarcoma patients who received chemotherapy and those who did not. The proportion of T YM cells was significantly decreased in patients compared with that in healthy donors. In healthy donors, anti‐ EBV CTL s were induced using mixed lymphocyte peptide culture, from not only T YM cells but also T CM and T EM cells. No CTL s directed to tumor‐associated antigens were induced. In sarcoma patients who did not receive chemotherapy, in addition to anti‐ EBV CTL s, CTL s directed to the tumor‐associated antigen PBF were induced from T YM , T CM and T EM cells. In sarcoma patients who received chemotherapy, EBV ‐specific CTL s were induced from T YM cells but were hardly induced from T EM cells. Interestingly, CTL s directed to the anti‐tumor‐associated antigen PBF were induced from T YM cells but not from the T CM and T EM cells in sarcoma patients who received chemotherapy. The findings suggest that T YM cells are resistant to chemotherapy and can firstly recover from the nadir. T YM cells might be important for immunological memory, especially in sarcoma patients receiving chemotherapy.