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DDX 4 (the human ortholog of  Drosophila  Vasa) is an  RNA  helicase and is present in the germ lines of all metazoans tested. It was historically thought to be expressed specifically in germline, but with additional organisms studied, it is now clear that in some animals  DDX 4/Vasa functions outside of the germline, in a variety of somatic cells in the embryo and in the adult. In this report, we document that  DDX 4 is widely expressed in soma‐derived cancer cell lines, including myeloma ( IM ‐9) and leukemia ( THP ‐1) cells. In these cells, the  DDX 4 protein localized to the mitotic spindle, consistent with findings in other somatic cell functions, and its knockout in  IM ‐9 cells compromised cell proliferation and migration activities, and downregulated several cell cycle/oncogene factors such as CyclinB and the transcription factor E2F1. These results suggest that  DDX 4 positively regulates cell cycle progression of diverse somatic‐derived blood cancer cells, implying its broad contributions to the cancer cell phenotype and serves as a potential new target for chemotherapy.

Germline factor DDX 4 functions in blood‐derived cancer cell phenotypes