Open AccessTranscriptomic analyses of RNA ‐binding proteins reveal eIF 3c promotes cell proliferation in hepatocellular carcinoma
Author(s) -
Li Tangjian,
Li Shengli,
Chen Di,
Chen Bing,
Yu Tao,
Zhao Fangyu,
Wang Qifeng,
Yao Ming,
Huang Shenglin,
Chen Zhiao,
He Xianghuo
Publication year - 2017
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13209
Subject(s) - biology , transcriptome , cancer research , hepatocellular carcinoma , gene expression , gene , cell cycle , rna , cell growth , downregulation and upregulation , rna binding protein , microbiology and biotechnology , genetics
RNA ‐binding proteins ( RBP s) play fundamental roles in the RNA life cycle. The aberrant expression of RBP s is often observed in human disease, including cancer. In this study, we screened for the expression levels of 1542 human RBP s in The Cancer Genome Atlas liver hepatocellular carcinoma samples and found 92 consistently upregulated RBP genes in HCC compared with normal samples. Additionally, we undertook a Kaplan–Meier analysis and found that high expression of 15 RBP genes was associated with poor prognosis in patients with HCC . Furthermore, we found that eIF 3c promotes HCC cell proliferation in vitro as well as tumorigenicity in vivo . Gene Set Enrichment Analysis showed that high eIF 3c expression is positively associated with KRAS , vascular endothelial growth factor, and Hedgehog signaling pathways, all of which are closely associated with specific cancer‐related gene sets. Our study provides the basis for further investigation of the molecular mechanism by which eIF 3c promotes the development and progression of HCC.