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Recent studies have demonstrated that mesenchymal stem cells ( MSC ) exhibit a tropism to tumors and form the tumor stroma. In addition, we found that  MSC  can secrete different types of factors. However, the involvement of  MSC ‐derived factors in human tongue squamous cell carcinoma ( TSCC ) growth has not been clearly addressed. The  CCN  family includes multifunctional signaling molecules that affect the initiation and development events of various tumors. In our study, we report that  CCN 2/connective tissue growth factor ( CTGF ) was the most highly induced among the  CCN  family members in  MSC  that were co‐cultured with  TSCC  cells. To evaluate the relationship between  CCN 2 and  TSCC  growth, we downregulated  MSC ‐derived  CCN 2 expression with sh RNA  targeting  CCN 2 and found that  MSC ‐secreted  CCN 2 promotes  TSCC  cell proliferation, migration and invasion. We also confirmed that  MSC ‐derived  CCN 2 partially accelerated tumor growth  in vitro . Taken together, these results suggest that  MSC ‐derived  CCN 2 contributes to the promotion of proliferation, migration and invasion of  TSCC  cells and may be a possible therapy target in the future.

Mesenchymal stem cell‐derived CCN 2 promotes the proliferation, migration and invasion of human tongue squamous cell carcinoma cells