Open AccessMesenchymal stem cell‐derived CCN 2 promotes the proliferation, migration and invasion of human tongue squamous cell carcinoma cells
Author(s) -
Wu YuLing,
Li HongYu,
Zhao XiaoPeng,
Jiao JiuYang,
Tang DongXiao,
Yan LingJian,
Wan Quan,
Pan ChaoBin
Publication year - 2017
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13202
Subject(s) - ctgf , mesenchymal stem cell , cell growth , cell migration , biology , cancer research , cell , microbiology and biotechnology , growth factor , chemistry , receptor , biochemistry
Recent studies have demonstrated that mesenchymal stem cells ( MSC ) exhibit a tropism to tumors and form the tumor stroma. In addition, we found that MSC can secrete different types of factors. However, the involvement of MSC ‐derived factors in human tongue squamous cell carcinoma ( TSCC ) growth has not been clearly addressed. The CCN family includes multifunctional signaling molecules that affect the initiation and development events of various tumors. In our study, we report that CCN 2/connective tissue growth factor ( CTGF ) was the most highly induced among the CCN family members in MSC that were co‐cultured with TSCC cells. To evaluate the relationship between CCN 2 and TSCC growth, we downregulated MSC ‐derived CCN 2 expression with sh RNA targeting CCN 2 and found that MSC ‐secreted CCN 2 promotes TSCC cell proliferation, migration and invasion. We also confirmed that MSC ‐derived CCN 2 partially accelerated tumor growth in vitro . Taken together, these results suggest that MSC ‐derived CCN 2 contributes to the promotion of proliferation, migration and invasion of TSCC cells and may be a possible therapy target in the future.