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Long non‐coding  RNA  (lnc RNA ) have been the focus of increasing attention due to the role they play in many diseases, including osteosarcoma. The function of taurine upregulated gene 1 ( TUG 1) and its mechanism in osteosarcoma remain unclear. In our research, we found that  TUG 1 was elevated and correlated with a poor prognosis in osteosarcoma patients. In addition, the following functional experiment showed that decreased  TUG 1 could remarkably inhibit osteosarcoma cell migration and invasion, indicating that  TUG 1 functioned as an oncogene in osteosarcoma. Moreover, we revealed that  TUG 1 and Rho‐associated coiled‐coil‐containing protein kinase 1 ( ROCK 1), a metastasis‐related gene targeted by micro RNA ‐335‐5p (miR‐335‐5p), had the same miR‐335‐5p combining site. The subsequent luciferase assay verified  TUG 1 was a target of miR‐335‐5p. Furthermore, the results of a real‐time quantitative  PCR  showed that  TUG 1 and miR‐335‐5p could affect each other's expression. respectively. Finally, we affirmed that  TUG 1 affected  ROCK 1 expression and  ROCK 1‐mediated migration/invasion by working as a competitive endogenous  RNA  (ce RNA ) via miR‐335‐5p. In summary, the findings of this study, based on ce RNA  theory, combining the research foundation of miR‐335‐5p and  ROCK 1, and taking  TUG 1 as a new study point, provide new insight into molecular‐level reversing migration and invasion of osteosarcoma.

Long non‐coding RNA TUG 1 promotes migration and invasion by acting as a ce RNA of miR‐335‐5p in osteosarcoma cells