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Although long non‐coding  RNA s (lnc RNA s) have been associated with a variety of cancers, the interplay between lnc RNA s and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen‐dependent lnc RNA  ,  POTEF ‐ AS 1 , whose expression was regulated by androgen receptor in two androgen‐dependent cells by using directional  RNA  sequencing analysis.   POTEF ‐ AS 1  promoted cell growth, repressed genes related to the Toll‐like receptor signaling and apoptosis pathways, and inhibited apoptosis in docetaxel‐treated  LNC aP cells. These findings suggest that   POTEF ‐ AS 1  would play a key role in the progression of prostate cancer by repressing Toll‐like receptor signaling.

Androgen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells