Open AccessAndrogen‐induced lncRNA POTEF‐AS1 regulates apoptosis‐related pathway to facilitate cell survival in prostate cancer cells
Author(s) -
Misawa Aya,
Takayama Kenichi,
Fujimura Tetsuya,
Homma Yukio,
Suzuki Yutaka,
Inoue Satoshi
Publication year - 2017
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13151
Subject(s) - androgen receptor , prostate cancer , cancer research , long non coding rna , rna , biology , androgen , signal transduction , apoptosis , toll like receptor , lncap , receptor , cancer , medicine , microbiology and biotechnology , endocrinology , gene , genetics , hormone , innate immune system
Although long non‐coding RNA s (lnc RNA s) have been associated with a variety of cancers, the interplay between lnc RNA s and androgen receptor signaling in prostate cancer is still unclear. We identified an androgen‐dependent lnc RNA , POTEF ‐ AS 1 , whose expression was regulated by androgen receptor in two androgen‐dependent cells by using directional RNA sequencing analysis. POTEF ‐ AS 1 promoted cell growth, repressed genes related to the Toll‐like receptor signaling and apoptosis pathways, and inhibited apoptosis in docetaxel‐treated LNC aP cells. These findings suggest that POTEF ‐ AS 1 would play a key role in the progression of prostate cancer by repressing Toll‐like receptor signaling.