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Aberrant sialylation profiles on the cell surface have been recognized for their potential diagnostic value in identifying the regulation of tumor properties in several cancers, including hepatocellular carcinoma ( HCC ). Recently, increasing evidence has suggested that the deregulation of micro RNA  (mi RNA ) is a common feature in human cancers. In this study, we found obvious upregulation of sialyltransferase  ST 3 GAL 6 both in  HCC  cell lines and in tissue samples. The altered expression of  ST 3 GAL 6 was found to correlate with cell proliferation, migration, and invasion ability in  HCC . Further investigation showed that miR‐26a negatively regulated  ST 3 GAL 6, inducing the suppression of cell proliferation, migration, and invasion  in vitro . Moreover, we identified the protein kinase B/mammalian target of rapamycin (Akt/ mTOR ) pathway as the target of  ST 3 GAL 6 based on Western blot analysis. Analysis of a xenograft mouse model showed that miR‐26a significantly reduced tumor growth by suppressing activation of the Akt/ mTOR  pathway by directly targeting  ST 3 GAL 6. In conclusion, these data indicate that  ST 3 GAL 6 promotes cell growth, migration, and invasion and mediates the effect of miR‐26a through the Akt/ mTOR  signaling pathway in HCC.

cancer science

Sialyltransferase  ST 3 GAL 6 mediates the effect of micro RNA ‐26a on cell growth, migration, and invasion in hepatocellular carcinoma through the protein kinase B/mammalian target of rapamycin pathway