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Physical activity ( PA ) is recommended to both promote and maintain health and prevent cancer by improving the body's  DNA  repair system, which is considered a mechanism of cancer prevention. However, associations between  PA  and urinary levels of 8‐hydroxydeoxyguanosine (8‐ OH ‐d G ), which reflects  DNA  damage, are unclear. This cross‐sectional study included 2370 men and 4052 women aged 45–74 years enrolled between 2010 and 2012. Habitual  PA  was assessed by single‐axis accelerometer and urinary 8‐ OH ‐d G  levels by automated  HPLC . Multiple linear regression analysis was used to examine the relationship between log‐transformed urinary 8‐ OH ‐d G  and total  PA  ( TPA ) and  PA  of moderate/vigorous intensity ( MVPA ; ≥3 metabolic equivalents), with adjustment for age, body mass index, energy intake, alcohol consumption, smoking status, daily coffee drinking, menopause status (in women), and  TPA  (for  MVPA ). On multivariate adjustment, urinary 8‐ OH ‐d G  levels were inversely correlated with  TPA  (β = −0.020,  P  < 0.01) in women, and this correlation was not changed by  PA  intensity. Conversely, urinary 8‐ OH ‐ dG  levels were inversely correlated with  MVPA  (β = −0.022,  P  < 0.05) in men, although the correlation with  TPA  was non‐significant. This inverse correlation was clearer in current smokers than in never or former smokers, although the interaction between smoking status and  MVPA  on urinary 8‐ OH ‐ dG  levels was non‐significant. In conclusion, greater  TPA  in women and greater  MVPA  in men were correlated with reduction in urinary 8‐ OH ‐ dG , suggesting sex‐specific effects of  MVPA  and  TPA  on protection from oxidative  DNA  damage. Increasing  PA  may mediate reduction in oxidative stress.

Intensity‐specific effect of physical activity on urinary levels of 8‐hydroxydeoxyguanosine in middle‐aged Japanese