Open AccessCD10 down expression in follicular lymphoma correlates with gastrointestinal lesion involving the stomach and large intestine
Author(s) -
Ohnishi Nobuhiko,
Takata Katsuyoshi,
MiyataTakata Tomoko,
Sato Yasuharu,
Tari Akira,
Gion Yuka,
NoujimaHarada Mai,
Taniguchi Kohei,
Tabata Tetsuya,
Nagakita Keina,
Omote Shizuma,
Takahata Hiroyuki,
Iwamuro Masaya,
Okada Hiroyuki,
Maeda Yoshinobu,
Yanai Hiroyuki,
Yoshino Tadashi
Publication year - 2016
Publication title -
cancer science
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.035
H-Index - 141
eISSN - 1349-7006
pISSN - 1347-9032
DOI - 10.1111/cas.13031
Subject(s) - lymphoma , stomach , pathology , follicular lymphoma , gastroenterology , malt lymphoma , medicine , lymphatic system , large intestine , lesion , biology , small intestine , pathological
Follicular lymphoma ( FL ) shows co‐expression of B‐cell lymphoma 2 ( BCL 2) and CD 10, whereas downexpression of CD 10 is occasionally experienced in gastrointestinal ( GI ) FL with unknown significance. Gastrointestinal FL is a rare variant of FL , and its similarity with mucosa‐associated lymphoid tissue lymphoma was reported. We investigated the clinicopathological and genetic features of CD 10 downexpressed ( CD 10 down ) GI ‐ FL . The diagnosis of CD 10 down FL was carried out with a combination of pathological and molecular analyses. The incidence of CD 10 down GI ‐ FL was shown in 35/172 (20.3%) cases, which was more frequent than nodal FL (3.5%, P < 0.001). The difference was additionally significant between GI ‐ FL and nodal FL when the analysis was confined to primary GI ‐ FL (55.2% vs 3.5%, P < 0.001). Compared to CD 10 + GI ‐ FL , CD 10 down GI ‐ FL significantly involved the stomach or large intestine ( P = 0.015), and additionally showed the downexpression of BCL 6 ( P < 0.001). The follicular dendritic cell meshwork often showed a duodenal pattern in the CD 10 down group ( P = 0.12). Furthermore, a lymphoepithelial lesion was observed in 5/12 (40%) gastric FL cases, which indicated caution in the differentiation of mucosa‐associated lymphoid tissue lymphoma. Molecular analyses were undertaken in seven cases of CD 10 down GI ‐ FL , and an identical clone was found between CD 10 down follicles and CD 10 + BCL 2 + neoplastic follicles. In the diagnosis of cases with CD 10 down BCL 2 + follicles, careful examination with molecular studies should be carried out.